Research Profiles: Quantitative proteomics goes global

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چکیده

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Quantitative proteomics in biological research.

Proteomics has enabled the direct investigation of biological material, at first through the analysis of individual proteins, then of lysates from cell cultures, and finally of extracts from tissues and biopsies from entire organisms. Its latest manifestation - quantitative proteomics - allows deeper insight into biological systems. This article reviews the different methods used to extract qua...

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Comparative and Quantitative Global Proteomics Approaches: An Overview

Proteomics became a key tool for the study of biological systems. The comparison between two different physiological states allows unravelling the cellular and molecular mechanisms involved in a biological process. Proteomics can confirm the presence of proteins suggested by their mRNA content and provides a direct measure of the quantity present in a cell. Global and targeted proteomics strate...

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ISBER Goes Global.

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Death Goes Global:

We present a case study—the U.S. death care industry—that largely violates the assumptions of foreign direction investment (FDI) theory. Based on this anomaly, we develop several questions to help us understand whether this is a unique case, whether other anomalies may also exist, and what this might mean for FDI theory. We hope to generate discussion to help us answer these questions.

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Global Subcellular Characterization of Protein Degradation Using Quantitative Proteomics*

Protein degradation provides an important regulatory mechanism used to control cell cycle progression and many other cellular pathways. To comprehensively analyze the spatial control of protein degradation in U2OS osteosarcoma cells, we have combined drug treatment and SILAC-based quantitative mass spectrometry with subcellular and protein fractionation. The resulting data set analyzed more tha...

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ژورنال

عنوان ژورنال: Analytical Chemistry

سال: 2001

ISSN: 0003-2700,1520-6882

DOI: 10.1021/ac012451n